So I got a new laptop, a Dell Latitude D630.  I decided to use BitLocker to encrypt the drive’s contents.   After using the Drive Preparation Tool, enabling the TPM chip in the laptops BIOS, and activating the chip,  I was presented with the following error within Vista while trying to turn on drive encryption:

Cannot run.

The path specified in the Boot Configuration Data (BCD) for a BitLocker Drive Encryption integrity-protected application is incorrect. Please verify and correct your BCD settings and try again.

So I did a little Google search and came across this Microsoft article which helped me resolve the problem.

http://support.microsoft.com/kb/929834

Here was the fix:

CAUSE

This problem occurs if one of the following entries in the Boot Configuration Data (BCD) store points to the incorrect partition:

•Windows Boot Manager

•Windows Memory Tester

•Resume from Hibernate

RESOLUTION

To resolve this problem, edit the following BCD entries:

•Windows Boot Manager
Set this entry to point to the system partition. To do this, follow these steps:

1.  Click Start , click All Programs, click Accessories, right-click Command Prompt, and then click Run as administrator.
If you are prompted for an administrator password or for confirmation, type your password or click Continue.

2.  At the command prompt, type bcdedit -set {bootmgr} device partition=S:
Note In this command, S: represents the drive letter for the system partition.

•Windows Memory Tester
Set this entry to point to the system partition. To do this, type the following command at the elevated command prompt:

bcdedit -set {memdiag} device partition=S:
Note In this command, S: represents the drive letter for the system partition.

•Resume from Hibernate
Set this entry to point to the operating system partition. This partition is also known as the boot partition. To do this, follow these steps:

1.  At the elevated command prompt, type bcdedit -enum all.
Note the identifier value for the Resume from Hibernate entry.

2.  At the elevated command prompt, type bcdedit -set {identifier} device partition=C:.

Note In this command, identifier represents the identifier value for the Resume from Hibernate entry in step 1 of this procedure. Also, C: represents the drive letter for the boot partition.